---
id: CVE-2025-68463
aliases:
  - GHSA-x3vf-39hj-gxr4
  - PYSEC-2026-1221
title: >-
  Biopython is vulnerable to doctype XML external entity (XXE) injection through
  Bio.Entrez
summary: >-
  Biopython is vulnerable to doctype XML external entity (XXE) injection through
  Bio.Entrez
severity: medium
cvss: 4.9
cvssVector: 'CVSS:3.1/AV:N/AC:H/PR:L/UI:N/S:C/C:L/I:N/A:L'
vendor: biopython
product: biopython
ecosystem: pip
affected:
  - biopython <= 1.86
published: '2025-12-18'
updated: '2026-07-07'
source: OSV
sourceUrl: 'https://osv.dev/vulnerability/GHSA-x3vf-39hj-gxr4'
references:
  - url: 'https://nvd.nist.gov/vuln/detail/CVE-2025-68463'
  - url: 'https://github.com/biopython/biopython/issues/5109'
  - url: >-
      https://github.com/biopython/biopython/commit/736c96f37b190732ecca9da80ad0cb9d4967214d
  - url: 'https://github.com/biopython/biopython'
  - url: 'https://github.com/biopython/biopython/blob/master/NEWS.rst'
  - url: 'https://pypi.org/project/biopython/1.87'
  - url: 'http://www.openwall.com/lists/oss-security/2026/05/08/16'
tags:
  - osv
  - pip
epss: 0.00316
epssPercentile: 0.21786
ingestedAt: '2026-07-08T18:25:54.101Z'
---

## Overview

Bio.Entrez in Biopython through 1.86 allows doctype XXE.

## Affected packages

- `biopython <= 1.86`

## Remediation

Refer to the advisory for the patched release.