{"id":"CVE-2025-68463","aliases":["GHSA-x3vf-39hj-gxr4","PYSEC-2026-1221"],"title":"Biopython is vulnerable to doctype XML external entity (XXE) injection through Bio.Entrez","summary":"Biopython is vulnerable to doctype XML external entity (XXE) injection through Bio.Entrez","severity":"medium","cvss":4.9,"cvssVector":"CVSS:3.1/AV:N/AC:H/PR:L/UI:N/S:C/C:L/I:N/A:L","vendor":"biopython","product":"biopython","ecosystem":"pip","affected":["biopython <= 1.86"],"published":"2025-12-18","updated":"2026-07-07","source":"OSV","sourceUrl":"https://osv.dev/vulnerability/GHSA-x3vf-39hj-gxr4","references":[{"url":"https://nvd.nist.gov/vuln/detail/CVE-2025-68463"},{"url":"https://github.com/biopython/biopython/issues/5109"},{"url":"https://github.com/biopython/biopython/commit/736c96f37b190732ecca9da80ad0cb9d4967214d"},{"url":"https://github.com/biopython/biopython"},{"url":"https://github.com/biopython/biopython/blob/master/NEWS.rst"},{"url":"https://pypi.org/project/biopython/1.87"},{"url":"http://www.openwall.com/lists/oss-security/2026/05/08/16"}],"tags":["osv","pip"],"epss":0.00316,"epssPercentile":0.24728,"ingestedAt":"2026-07-08T18:25:54.101Z","slug":"CVE-2025-68463","body":"## Overview\n\nBio.Entrez in Biopython through 1.86 allows doctype XXE.\n\n## Affected packages\n\n- `biopython <= 1.86`\n\n## Remediation\n\nRefer to the advisory for the patched release.","depth":"sunlit","depthScore":27,"depthScoreParts":{"impact":27,"likelihood":0.1,"exploitation":0,"ransomware":0},"changes":[]}